Hydrogel Drug Release Systems

How can all the ingredients in Morgellons end up in the same package?
What is the delivery system?

In the past pharmaceuticals have primarily consisted of fast-acting compounds dispensed orally or by injection.
In the past 3 decades, understanding of the human body has resulted in discoveries of bioactive molecules and gene therapies.
Modern Time Release drug delivery systems deploy medications to parts of the body and control them by means of a physiological or chemical trigger.
The use of polymeric microspheres, polymer micelles and hydrogel-type materials have enhanced specific absorption, controlled degradation and lowered toxicity.
Polymers are defined as very large macromolecules consisting of repeating units of monomers.
Polymeric materials are easy to procss and their chemical and physical properties can be controlled via molecular synthesis.

There are two broad categories of polymer systems called “microspheres”: Reservoir Devices and Matrix Devices.
Reservoir Devices: Encapsulated pharmaceutical products (drugs) within a polymer shell.
Matrix Devices: The drug is physically entrapped in a polymer network.
Biodegradable polymer systems degrade into biologically acceptable compounds by hydrolysis and the medication is left behind.
The degradation process involves the breakdown of polymers into lactic and glycolic acids which are reduced to carbon dioxide and water and expelled easily by the body.
Early research focused on naturally occurring polymers (collagen and cellulose) but recent focus is on chemical synthesis of polyanhydrides, polyesters, polyacrylic acids, poly (methyl methacrylates) and polyurethanes.
By adjusting the rate of matrix degradation, you can control the rate of drug delivery.
A fast-degrading matrix consists of a hydrophilic, amorphous, low-molecular-weight polymer containing heteroatoms (atoms other than carbon) in its backbone and is grown either stepwise or through condensation reactions.
Some carrier systems are single polymeric networks and some are block copolymer networks formed through joint polymerization of two or more different monomers.
Copolymers are two polymers in the same matrix.
These supramolecular networks, when composed of cross-linked combinations of hydrophilic and hydrophobic monomers, are called POLYMER MICELLES.
Polymer micelles self-arrange in shell-like structure with their hydrophilic and hydrophobic ligands aligned on opposing sides.
Micelles are only tens of nanometers in diameter and are thus ideally sized for enclosing individual drug molecules.
Hydrpphilic outer shells help protect the core and the contents from chemical attack by body fluids.
The drugs are released as the polymer degrades.
The specificity of delivery is controlled by the synthetic design. Micelles with sugar-group ligands attached specifically target glyco-receptors in cellular plasma membranes.
Most Micelle-based delivery systems are a triblock network or a polypeptide and poly (ethylene oxide) combination.
When dosed intravenously, the system can withstand the body’s normal blood circulation and effectively deliver the medication to a solid cancerous tumour.
Another polymer matrix system uses conducting, electroactive polymers as a medium-sensing, bioactive molecule-releasing system.
Drug delivery with conducting polymer membranes is achieved through the controlled ionic transport of counterions (dopants) in and out of the membranes.
A dopant is an impurity.
Redox reactions regulate electrochemical switching, allowing electrostatically entrapped, ionic dopants to be either retained or released.
The drug delivery rate, chemical sensing and electrochemical triggering can be synthetically and precisely controlled.
Hydrogel-type materials can be used to shepherd various medications through the stomach and into the more alkaline intestine.
Hydrogels are cross-linked, hydrophilic, three-dimensional polymer networks that are highly permeable to various drug compounds.
Hydrogel’s chemical composition reacts to internal and external changes in pH, magnetic or electrical fields, change in temperature and ultrasound irradiation which trigger the swelling effect.
Once triggered, the rate of entrapped drug release is determined solely by the cross-linking ration of the polymer network.
Research into hydrogel delivery systems has focused primarily on systems containing polyacrylic acid (PAA) backbones.
Polyacrylic acid hydrogels are super-absorbent and form extended polymer networks through hydrogen bonding.
Polyacrylic acid hydrogels are excellent bioadhesive which means they can adhere to mucosal linings within the gastrointestinal tract for extended periods, releasing encapsulated medications slowly over time.
Two other drug transport systems involve the use of DENDRIMERS (highly branched globular synthetic macromolecules) and modified BUCKYBALLS to deploy medications capable of providing targeted drug delivery.
Dendritic macromolecules make suitable carrier systems because their size and structure can be controlled by synthetic means.
Dendritic macromolecules can be easily processed and made biocompatible and biodegradable.
They can be used to encapsulate individual small drug molecules in the same manner as polymer micelles. They are UNIMOLECULAR NANOCAPSULES.
They also serve as “hubs” onto which large numbers of drug molecules can be attached via covalent bonds.
A single denrimer may transport extremely high densities of drug molecules.
Another drug delivery system is the CARBON METALLOFULLERENE CAGES which enclose metal ions.
Carbon fullerene cages can deliver radioactive atoms directly to diseased tissues in cancer tumours. They can also be weaponized.
Fullerenes are ideally suited for this because of their size and resistence to biochemical attack from the body.
Radioactive atoms may readily be transported within the balls minimizing radiation damage to hralthy tissues.
Modified soluble metallofullerenes preferentially bind to human bone. The presence of an unpaired electron renders synthesized metallofullerenes magnetic.
Drug delivery systems also include aerosol inhalation devices, transdermal methodologies, forced-pressure injectables and biodegradable polymer networks designed to transport gene therapies.
Another system is in-situ-crosslinking polyethylene oxide based networks structurally designed to release DNA slowly over time.
Sustained release delivery systems increase the long-term availability of the DNA and thus achieve sustained systemic protein production.

Read “Morgellons Definitive Cure Post” For A Very Helpful Information On How You Can Recover From Morgellons.

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